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At Arizona State University 


67. J. Geiger, R. Sexton, Z. Al-Sahouri, M.-Y. Lee, E. Chun, K.G. Harikumar, L.J. Miller, O. Beckstein and W Liu*.  Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors. Biochim Biophys Acta Biomembr. 2021 Jan 11:183557. doi: 10.1016/j.bbamem.2021.183557. Online ahead of print.


66. M.-Y. Lee, J. Geiger, A. Ishchenko, G.W. Han, A. Barty, T.A. White, C. Gati, A. Batyuk, M.S. Hunter, A. Aquila, S. Boutet, U. Weierstall, V. Cherezov and and W Liu*. (2020) Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase. IUCrJ. Vol 7(6), 976-984.

65. L. Zhu, X. Chen, E.E. Abola, L. Jing and W Liu*. (2020) Serial Crystallography for Structure-Based Drug Discovery. Trends Pharmacol Sci. Available online 16 September 2020.

64. M. Su, L. Zhu, Y. Zhang, N. Paknejad, R. Dey, J. Huang, M.-Y. Lee, D, Williams, K.D. Jordan, E.T. Eng, O.P. Ernst, J.R. Meyerson, R.K. Hite, T. Walz, W Liu* and X-Y. Huang*. (2020) Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor. Molecular Cell. Available online 19 August 2020.

63. L. Zhu, G. Bu, L. Jing, D. Shi, M.-Y. Lee, T. Gonen, W Liu* and B.L. Nannenga*. (2020) Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED. Structure. Available online 30 July 2020.

62. J. Zook, M. Shekhar, D. Hansen, C. Conrad, T. Grant, C. Gupta, T. White, A. Barty, S. Basu, Y. Zhao, N. Zatsepin, A. Ishchenko, A. Batyuk, C. Gati, C. Li, L. Galli, J. Coe, M. Hunter, M. Liang, U. Weierstall, G. Nelson, D. James, B. Stauch, F. Craciunescu, D. Thifault, W. Liu, V. Cherezov, A. Singharoy, P. Fromme. (2020) XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia. Structure. Available online 5 March 2020.


61. A. Ishchenko, B. Stauch, G.W. Han, A. Batyuk, A. Shiriaeva, C. Li, N. Zatsepin, U. Weierstall, W. Liu, E. Nango, T. Nakane, R. Tanaka, K. Tono, Y. Joti, S. Iwata, I. Moraes, C. Gati, and V. Cherezov. (2019) Toward G protein-coupled receptor structure-based drug design using X-ray lasers. IUCrJ. Vol. 6, 1106-1119.

60. A. Luginina, A. Gusach, E. Marin, A. Mishin, R. Brouillette, P. Popov, A. Shiriaeva, É. Besserer-Offroy, J. Longpré, E. Lyapina, A. Ishchenko, N. Patel, V. Polovinkin, N. Safronova, A. Bogorodskiy, E. Edelweiss, H. Hu, U. Weierstall, W. Liu, A. Batyuk, V. Gordeliy, G.W. Han, P. Sarret, V. Katritch, V. Borshchevskiy, and V. Cherezov. (2019) Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv. Vol. 5, no. 10, eaax2518.

59. J. Duan, J. Li, G.L. Chen, Y. Ge, J. Liu, K. Xie, X. Peng, W. Zhou, J. Zhong, Y. Zhang, J. Xu, C. Xue, B. Liang, L. Zhu, W. Liu, C. Zhang, X.L. Tian, J. Wang, D.E. Clapham, B. Zeng, Z. Li, J. Zhang. (2019) Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Sci Adv. Jul 24;5(7):eaaw7935.

58. B. Stauch, L.C. Johansson, J.D. McCorvy, N. Patel, G.W. Han, X-P. Huang, C. Gati, A. Batyuk, S.T. Slocum, A. Ishchenko, W. Brehm, T.A. White, N. Michaelian, C. Madsen, L. Zhu, T.D. Grant, J.M. Grandner, A. Shiriaeva, R.H. J. Olsen, A.R. Tribo, S. Yous, R.C. Stevens, U. Weierstall, V. Katritch, B.L. Roth*, W Liu*, V. Cherezov*. (2019)  Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature.  569: 284-298.

57. L.C. Johansson, B. Stauch, J.D. McCorvy, G.W. Han, N. Patel, X-P Huang, A. Batyuk, C. Gati, S.T. Slocum, C. Li, J.M. Grandner, S. Hao, R.H.J. Olsen, A.R. Tribo, S. Zaare, L. Zhu, N.A. Zatsepin, U. Weierstall, S. Yous, R.C. Stevens, W. Liu, B.L. Roth*, V. Katritch*, V. Cherezov*. (2019) XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. Nature. 569: 289-292.

56. J.M. Martin-Garcia, L. Zhu, D. Mendez, M.-Y. Lee, E. Chun, C. Li, H. Hu, G. Subramanian, D. Kissick, C. Ogata, R. Henning, A. Ishchenko, Z. Dobson, S. Shang, U. Weierstall, J.C.H. Spence, P. Fromme, N.A. Zatsepin, R.F. Fischetti, V. Cherezov*, and W. Liu*. (2019) High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. IUCrJ.

55. S. Du, L. Zhu, Y. Wang, J. Liu, D. Zhang, Y. Chen, Q. Peng, W. Liu*, and B. Liu. (2018) SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer Cell Int. 2019 Jan 3;19:4. doi: 10.1186/s12935-018-0722-9. eCollection 2019.

54. M. Audet, K.L. White, B. Breton, B. Zarzycka, G.W. Han, Y. Lu, C. Gati, A. Batyuk, P. Popov, J. Velasquez, D. Manahan, H. Hu, U. Weierstall, W. Liu, W. Shui, V. Katritch, V. Cherezov, M.A. Hanson, R.C. Stevens. (2019) Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nat Chem Biol. 15, 11–17.


53. E.E. Abola, U. Weierstall, W. Liu and V. Cherezov. (2018) Delivery of GPCR Crystals for Serial Femtosecond Crystallography. in Protein Crystallography: Challenges and Practical Solutions Chapter 2: 28-53.

52. L. Zhu, M.Y. Lee, E. Chun, B. Liu, and W. Liu*. (2018) Overview of Biochemical Assays in Lipidic Cubic Phase. Trends Biochem Sci  2018 Sep 19. pii: S0968-0004(18)30159-2. doi: 10.1016/j.tibs.2018.08.008. [Epub ahead of print]

51. T. Lan, J.L. Wierman, M.W. Tate, H.T. Philipp, J.M. Martin-Garcia, L. Zhu, D. Kissick, P. Fromme, R.F. Fischetti, W. Liu, V. Elser and S.M. Gruner. (2018) Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source. IUCrJ


50. D. Li, S. Liu, L. Zhu, Y. Wang, Y. Chen, J. Liu, G. Hu, X. Yu, J. Li, Z. Wu, H. Lu, W. Liu*, and B. Liu*. (2017) FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. Oncotarget.

49. A. Ishchenko, D. Wacker, M. Kapoor, A. Zhang, G.W. Han, S. Basu, N. Patel, M. Messerschmidt, U. Weierstall, W. Liu, V. Katritch, B.L. Roth, R.C. Stevens, and Vadim Cherezov. (2017) Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proc Natl Acad Sci.114: 8223-8228.

 48. J.M. Martin-Garcia, C.E. Conrad, G. Nelson, N. Stander, N.A. Zatsepin, J. Zook, L. Zhu, J. Geiger, E. Chun, D. Kissick, M.C. Hilgart, C. Ogata, A. Ishchenko, N. Nagaratnam, S. Roy-Chowdhury, J. Coe, G. Subramanian, A. Schaffer, D. James, G. Ketwala, N. Venugopalan, S. Xu, S. Corcoran, D. Ferguson, U. Weierstall, J.C. H. Spence, V. Cherezov, P. Fromme, R.F. Fischetti, W. Liu*. (2017) Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation. IUCrJ. 4:439-454.

47. H. Zhang, A. Qiao, D. Yang, L. Yang, A. Dai, C. de Graaf, S. Reedtz-Runge, V. Dharmarajan, H. Zhang, G. W. Han, T.D. Grant, R.G. Sierra, U. Weierstall, G. Nelson, W. Liu, Y. Wu, L. Ma, X. Cai, G. Lin, X. Wu, Z. Geng, Y. Dong, G. Song, P.R. Griffin, J. Lau, V. Cherezov, H. Yang, M.A. Hanson, R.C. Stevens, Q.Zhao, H. Jiang, M. Wang and B. Wu. (2017) Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 546, 259–264.

 46. H. Zhang, G.W. Han, A. Batyuk, A. Ishchenko, K.L. White, N. Patel, A. Sadybekov, B. Zamlynny, M.T. Rudd, K. Hollenstein, A. Tolstikova, T.A. White, M.S. Hunter, U. Weierstall, W. Liu, K. Bagaoglu, E.L. Moore, R.D. Katz, J.M. Shipman, M. Garcia-Calvo, S. Sharma, P. Sheth, S.M. Soisson, R.C. Stevens, V. Katritch and V. Cherezov. (2017) Structural basis for selectivity and diversity in angiotensin II receptors. Nature.  544, 327–332.


45. J. Xiang, E. Chun, C. Liu, L. Jing, Z. Al-Sahouri, L. Zhu, and W. Liu*. (2016) Successful Strategies to Determine High-Resolution Structures of GPCRs. Trends Pharmacol Sci  2016 Dec;37(12):1055-1069.

44. A. Batyuk, L. Galli, A. Ishchenko, G.W. Han, C. Gati, P.A. Popov, M-Y Lee, B. Stauch, T.A. White, A. Barty, A. Aquila, M.S. Hunter, M. Liang, S. Boutet, M. Pu, Z-J Liu, G. Nelson, D. James, C. Li, Y. Zhao, J.C.H. Spence, W. Liu, P. Fromme, V. Katritch, U. Weierstall, R.C. Stevens and V. Cherezov. (2016) Native phasing of x-ray free-electron laser data for a G protein–coupled receptor. Science Advances  Vol. 2, no. 9, e1600292.

43. A. Ishchenko, V. Cherezov, W. Liu*. (2016) Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography. J. Vis. Exp. (115), e54463, doi:10.3791/54463.

42. T.A. White, A. Barty, W. Liu, A. Ishchenko, H. Zhang, C. Gati, N.A. Zatsepin, S. Basu, D. Oberthür, M. Metz, K.R. Beyerlein, C.H. Yoon, O.M. Yefanov, D. James, D. Wang, M. Messerschmidt, J.E. Koglin, S. Boutet, U. Weierstall, V. Cherezov. (2016) Serial femtosecond crystallography datasets from G protein-coupled receptors. Sci. Data, 3:160057. doi: 10.1038/sdata.2016.57.

41. L. Zhu, U. Weierstall, V. Cherezov, W. Liu*. (2016) Serial Femtosecond Crystallography of Membrane Proteins. Adv Exp Med Biol. 2016;922:151-60. doi: 10.1007/978-3-319-35072-1_11.

40. X.E. Zhou, X. Gao, A. Barty, Y. Kang, Y. He, W. Liu, A. Ishchenko, T.A. White, O. Yefanov, G.W. Han, Q. Xu, P. W. de Waal, K.M. Suino-Powell, S. Boutet, G.J. Williams, M. Wang, D. Li, M. Caffrey, H.N. Chapman, J.C.H. Spence, P. Fromme, U. Weierstall, R.C. Stevens, V. Cherezov, K. Melcher, H.E. Xu, X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, Sci. Data, 3:160021. DOI: 10.1038/sdata.2016.21


39.   H.T. Zhang, H. Unal, C. Gati, G.W. Han, W. Liu, N.A. Zatsepin, D. James, D.J. Wang, G. Nelson, U. Weierstall, M.R. Sawaya, Q.P. Xu, M. Messerschmidt, G.J. Williams, S. Boutet, O.M. Yefanov, T.A. White, C. Wang, A. Ishchenko, K.C. Tirupula, R. Desnoyer, J. Coe, C.E. Conrad, P. Fromme, R.C. Stevens, V. Katritch, S.S. Karnik, V. Cherezov, Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography, Cell, 161(2015) 833-44.

38.   D. Li, P.J. Stansfeld, M.S. Sansom, A. Keogh, L. Vogeley, N. Howe, J.A. Lyons, D. Aragao, P. Fromme, R. Fromme, S. Basu, I. Grotjohann, C. Kupitz, K. Rendek, U. Weierstall, N.A. Zatsepin, V. Cherezov, W. Liu, S. Bandaru, N.J. English, C. Gati, A. Barty, O. Yefanov, H.N. Chapman, K. Diederichs, M. Messerschmidt, S. Boutet, G.J. Williams, M. Marvin Seibert, M. Caffrey, Ternary structure reveals mechanism of a membrane diacylglycerol kinase, Nat Commun, 6(2015) 10140.

37. R.M. Lawrence, C.E. Conrad, N.A. Zatsepin, T.D. Grant, H.G. Liu, D. James, G. Nelson, G. Subramanian, A. Aquila, M.S. Hunter, M.N. Liang, S. Boutet, J. Coe, J.C.H. Spence, U. Weierstall, W. Liu, P. Fromme, V. Cherezov, B.G. Hogue, Serial femtosecond X-ray diffraction of enveloped virus microcrystals, Structural Dynamics, 2(2015).

36.  Jim Hicks Peter Kuhn, RODRIGUEZ Angel Ernesto DAGO, Anders Carlsson, Wei Liu, Genotypic and phenotypic analysis of circulating tumor cells to monitor tumor evolution in prostate cancer patients. US Patent App. WO 2015048740 A1

35.   Y. Kang, X.E. Zhou, X. Gao, Y. He, W. Liu, A. Ishchenko, A. Barty, T.A. White, O. Yefanov, G.W. Han, Q. Xu, P.W. de Waal, J. Ke, M.H. Tan, C. Zhang, A. Moeller, G.M. West, B.D. Pascal, N. Van Eps, L.N. Caro, S.A. Vishnivetskiy, R.J. Lee, K.M. Suino-Powell, X. Gu, K. Pal, J. Ma, X. Zhi, S. Boutet, G.J. Williams, M. Messerschmidt, C. Gati, N.A. Zatsepin, D. Wang, D. James, S. Basu, S. Roy-Chowdhury, C.E. Conrad, J. Coe, H. Liu, S. Lisova, C. Kupitz, I. Grotjohann, R. Fromme, Y. Jiang, M. Tan, H. Yang, J. Li, M. Wang, Z. Zheng, D. Li, N. Howe, Y. Zhao, J. Standfuss, K. Diederichs, Y. Dong, C.S. Potter, B. Carragher, M. Caffrey, H. Jiang, H.N. Chapman, J.C. Spence, P. Fromme, U. Weierstall, O.P. Ernst, V. Katritch, V.V. Gurevich, P.R. Griffin, W.L. Hubbell, R.C. Stevens, V. Cherezov, K. Melcher, H.E. Xu, Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, Nature, 523(2015) 561-7.

34.  R. Fromme, A. Ishchenko, M. Metz, S.R. Chowdhury, S. Basu, S. Boutet, P. Fromme, T.A. White, A. Barty, J.C. Spence, U. Weierstall, W. Liu*, V. Cherezov, Serial femtosecond crystallography of soluble proteins in lipidic cubic phase, IUCrJ, 2(2015) 545-51.

33.  G. Fenalti, N.A. Zatsepin, C. Betti, P. Giguere, G.W. Han, A. Ishchenko, W. Liu, K. Guillemyn, H. Zhang, D. James, D. Wang, U. Weierstall, J.C.H. Spence, S. Boutet, M. Messerschmidt, G.J. Williams, C. Gati, O.M. Yefanov, T.A. White, D. Oberthuer, M. Metz, C.H. Yoon, A. Barty, H.N. Chapman, S. Basu, J. Coe, C.E. Conrad, R. Fromme, P. Fromme, D. Tourwe, P.W. Schiller, B.L. Roth, S. Ballet, V. Katritch, R.C. Stevens, V. Cherezov, Structural basis for bifunctional peptide recognition at human delta-opioid receptor, Nature Structural & Molecular Biology, 22(2015) 265-8.


Before Arizona State University (ASU)


32.  X. Yin, H.H. Xu, M. Hanson, W. Liu*, GPCR Crystallization Using Lipidic Cubic Phase Technique, Current Pharmaceutical Biotechnology, 15(2014) 971-9.

31. U. Weierstall, D. James, C. Wang, T.A. White, D.J. Wang, W. Liu, J.C.H. Spence, R.B. Doak, G. Nelson, P. Fromme, R. Fromme, I. Grotjohann, C. Kupitz, N.A. Zatsepin, H.G. Liu, S. Basu, D. Wacker, G.W. Han, V. Katritch, S. Boutet, M. Messerschmidt, G.J. Williams, J.E. Koglin, M.M. Seibert, M. Klinker, C. Gati, R.L. Shoeman, A. Barty, H.N. Chapman, R.A. Kirian, K.R. Beyerlein, R.C. Stevens, D.F. Li, S.T.A. Shah, N. Howe, M. Caffrey, V. Cherezov, Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography, Nature Communications, 5(2014).

30. W. Liu, D. Wacker, C. Wang, E. Abola, V. Cherezov, Femtosecond crystallography of membrane proteins in the lipidic cubic phase, Philosophical Transactions of the Royal Society B-Biological Sciences, 369(2014).

29.  W. Liu, A. Ishchenko, V. Cherezov, Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography, Nature Protocols, 9(2014) 2123-34.

28.  D.L. Gater, O. Saurel, I. Iordanov, W. Liu, V. Cherezov, A. Milon, Two classes of cholesterol binding sites for the beta2AR revealed by thermostability and NMR, Biophys J, 107(2014) 2305-12.


27.  C. Wang, H.X. Wu, V. Katritch, G.W. Han, X.P. Huang, W. Liu, F.Y. Siu, B.L. Roth, V. Cherezov, R.C. Stevens, Structure of the human smoothened receptor bound to an antitumour agent, Nature, 497(2013) 338-+.

26.  C. Wang, Y. Jiang, J.M. Ma, H.X. Wu, D. Wacker, V. Katritch, G.W. Han, W. Liu, X.P. Huang, E. Vardy, J.D. McCorvy, X. Gao, X.E. Zhou, K. Melcher, C.H. Zhang, F. Bai, H.Y. Yang, L.L. Yang, H.L. Jiang, B.L. Roth, V. Cherezov, R.C. Stevens, H.E. Xu, Structural Basis for Molecular Recognition at Serotonin Receptors, Science, 340(2013) 610-4.

25.  D. Wacker, C. Wang, V. Katritch, G.W. Han, X.P. Huang, E. Vardy, J.D. McCorvy, Y. Jiang, M.H. Chu, F.Y. Siu, W. Liu, H.E. Xu, V. Cherezov, B.L. Roth, R.C. Stevens, Structural Features for Functional Selectivity at Serotonin Receptors, Science, 340(2013) 615-9.

24. F.Y. Siu, M. He, C. de Graaf, G.W. Han, D.H. Yang, Z.Y. Zhang, C.H. Zhou, Q.P. Xu, D. Wacker, J.S. Joseph, W. Liu, J. Lau, V. Cherezov, V. Katritch, M.W. Wang, R.C. Stevens, Structure of the human glucagon class B G-protein-coupled receptor, Nature, 499(2013) 444-+.

23.  J.S. Santos, G.A. Asmar-Rovira, G.W. Han, W. Liu, R. Syeda, V. Cherezov, K.A. Baker, R.C. Stevens, M. Montal, Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes (vol 287, pg 43063, 2012), Journal of Biological Chemistry, 288(2013) 3476-.

22.  W. Liu, D. Wacker, C. Gati, G.W. Han, D. James, D.J. Wang, G. Nelson, U. Weierstall, V. Katritch, A. Barty, N.A. Zatsepin, D.F. Li, M. Messerschmidt, S. Boutet, G.J. Williams, J.E. Koglin, M.M. Seibert, C. Wang, S.T.A. Shah, S. Basu, R. Fromme, C. Kupitz, K.N. Rendek, I. Grotjohann, P. Fromme, R.A. Kirian, K.R. Beyerlein, T.A. White, H.N. Chapman, M. Caffrey, J.C.H. Spence, R.C. Stevens, V. Cherezov, Serial Femtosecond Crystallography of G Protein-Coupled Receptors, Science, 342(2013) 1521-4.

21.  J.R. Lane, P. Chubukov, W. Liu, M. Canals, V. Cherezov, R. Abagyan, R.C. Stevens, V. Katritch, Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors, Molecular Pharmacology, 84(2013) 794-807.

20.  H. Gutierrez-de-Teran, A. Massink, D. Rodriguez, W. Liu, G.W. Han, J.S. Joseph, I. Katritch, L.H. Heitman, L.Z. Xia, A.P. IJzerman, V. Cherezov, V. Katritch, R.C. Stevens, The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A(2A) Adenosine G Protein-Coupled Receptor, Structure, 21(2013) 2175-85.


19.  H.X. Wu, D. Wacker, M. Mileni, V. Katritch, G.W. Han, E. Vardy, W. Liu, A.A. Thompson, X.P. Huang, F.I. Carroll, S.W. Mascarella, R.B. Westkaemper, P.D. Mosier, B.L. Roth, V. Cherezov, R.C. Stevens, Structure of the human kappa-opioid receptor in complex with JDTic, Nature, 485(2012) 327-U69.

18.  A.A. Thompson, W. Liu, E. Chun, V. Katritch, H.X. Wu, E. Vardy, X.P. Huang, C. Trapella, R. Guerrini, G. Calo, B.L. Roth, V. Cherezov, R.C. Stevens, Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic, Nature, 485(2012) 395-U150.

17.  W. Liu, E. Chun, A.A. Thompson, P. Chubukov, F. Xu, V. Katritch, G.W. Han, C.B. Roth, L.H. Heitman, A.P. IJzerman, V. Cherezov, R.C. Stevens, Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions, Science, 337(2012) 232-6.

16.  J.W. Fairman, N. Dautin, D. Wojtowicz, W. Liu, N. Noinaj, T.J. Barnard, E. Udho, T.M. Przytycka, V. Cherezov, S.K. Buchanan, Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. coli and Enteropathogenic Y. pseudotuberculosis, Structure, 20(2012) 1233-43.

15.  E. Chun, A.A. Thompson, W. Liu, C.B. Roth, M.T. Griffith, V. Katritch, J. Kunken, F. Xu, V. Cherezov, M.A. Hanson, R.C. Stevens, Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors, Structure, 20(2012) 967-76.

14.  Michael A. Hanson, Christopher B. Roth,Raymond C. Stevens, Joshua M. Kunken,Mark T. Griffith, Aaron A. Thompson, Wei Liu, Fei Xu, Vsevolod Katritch, Novel fusion partners for the purpose of crystallizing g-protein coupled receptors, US Patent App. 13/470,104


13.  F. Xu, W. Liu, M.A. Hanson, R.C. Stevens, V. Cherezov, Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases, Cryst Growth Des, 11(2011) 1193-201.

12.  T. Tiefenbrunn, W. Liu, Y. Chen, V. Katritch, C.D. Stout, J.A. Fee, V. Cherezov, High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment, PLoS One, 6(2011) e22348.

11.  T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, G.W. Han, T. Kobayashi, R.C. Stevens, S. Iwata, Structure of the human histamine H1 receptor complex with doxepin, Nature, 475(2011) 65-70.

10.  W. Liu, V. Cherezov, Crystallization of membrane proteins in lipidic mesophases, J Vis Exp, (2011).

9.   J.S. Joseph, W. Liu, J. Kunken, T.M. Weiss, H. Tsuruta, V. Cherezov, Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering, Methods, 55(2011) 342-9.


8.   B. Wu, E.Y. Chien, C.D. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F.C. Bi, D.J. Hamel, P. Kuhn, T.M. Handel, V. Cherezov, R.C. Stevens, Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists, Science, 330(2010) 1066-71.

7.   W. Liu, M.A. Hanson, R.C. Stevens, V. Cherezov, LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment, Biophys J, 98(2010) 1539-48.

6.   E.Y. Chien, W. Liu, Q. Zhao, V. Katritch, G.W. Han, M.A. Hanson, L. Shi, A.H. Newman, J.A. Javitch, V. Cherezov, R.C. Stevens, Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist, Science, 330(2010) 1091-5.


5.   V. Cherezov, W. Liu, J.P. Derrick, B. Luan, A. Aksimentiev, V. Katritch, M. Caffrey, In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin, Proteins, 71(2008) 24-34.


4.  Membrane Protein Crystallization in the Lipid Cubic Phase: Testing Hypotheses Relating to Reconstitution, W Liu,The Ohio State University


3.   W. Liu, M. Caffrey, Interactions of tryptophan, tryptophan peptides, and tryptophan alkyl esters at curved membrane interfaces, Biochemistry, 45(2006) 11713-26.

2.   V. Cherezov, E. Yamashita, W. Liu, M. Zhalnina, W.A. Cramer, M. Caffrey, In meso structure of the cobalamin transporter, BtuB, at 1.95 angstrom resolution, Journal of Molecular Biology, 364(2006) 716-34.


1.   W. Liu, M. Caffrey, Gramicidin structure and disposition in highly curved membranes, Journal of Structural Biology, 150(2005) 23-40.

* Correspondng author